337121 comments

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  28/12/22

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  Methods: Completely different concentrations of FAUC
  213 were screened for effects on spontaneous, in addition to amphetamine-induced,
  locomotor exercise and apomorphine-induced prepulse disruption. FAUC
  213) is a highly selective antagonist at the dopamine D(4) receptor subtype.
  The selective D(4) antagonist FAUC 213, due to this fact, just isn't believed to mediate the
  above-mentioned effects via D(2) receptor antagonism, but a partial involvement of 5-HT(2)- and alpha(1)-receptors cannot be ruled out at
  present. It was designed as a derivative of two partial
  antagonists and has been confirmed to be a complete antagonist in mitogenesis assay.
  Strategies: PK/PD of colistin was studied in thigh and lung infection models
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  of the three strains were colistin heteroresistant).
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  28/12/22

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